The Anti-CCP (Cyclic Citrullinated Peptide) Antibody Test is a blood test used primarily for diagnosing rheumatoid arthritis (RA) and other autoimmune diseases.
Anti-CCP antibodies are specific proteins produced by the immune system that target cyclic citrullinated peptides, which are modified proteins in the body.
The Anti-CCP test measures the concentration of anti-cyclic citrullinated peptide antibodies in the blood. These antibodies are highly specific to rheumatoid arthritis and are produced when the immune system mistakenly targets citrullinated proteins in the body. A positive Anti-CCP test is considered a hallmark of rheumatoid arthritis, making it a critical tool for early diagnosis and disease management.
The Anti-CCP test normal range is typically between 0 and 20 U/mL, though this can vary slightly by laboratory standards. Here’s how the levels are generally interpreted:
Low or Negative (0 - 20 U/mL): Generally considered within the normal range and indicates that the individual is less likely to have rheumatoid arthritis.
Moderate to High (20 - 60 U/mL): Indicates a higher likelihood of RA and may necessitate further diagnostic evaluation and monitoring.
High Anti-CCP Levels (>60 U/mL): Strongly suggest rheumatoid arthritis or a more aggressive disease course, requiring close monitoring and intervention.
It’s important to note that high Anti-CCP levels may also appear in other conditions, though they are most closely associated with RA. A positive Anti-CCP test can indicate the presence of RA and may even precede physical symptoms, allowing for early intervention.
Early Detection of Rheumatoid Arthritis: The Anti-CCP test aids in identifying RA before significant joint damage occurs, enabling timely treatment and management.
Predicting Disease Progression: High anti-CCP levels can signal a more aggressive form of RA, allowing healthcare providers to tailor treatment plans accordingly.
Differentiation from Other Conditions: Since Anti-CCP is specific to RA, it helps differentiate RA from other types of arthritis or autoimmune conditions.
Association with Cancer and Other Diseases: While rare, high levels of Anti-CCP may occasionally appear in cancer and other autoimmune disorders, warranting further investigation.
A positive Anti-CCP test is most commonly associated with rheumatoid arthritis but may also appear in:
Systemic Lupus Erythematosus (SLE)
Psoriatic Arthritis
Sjogren’s Syndrome
Certain cancers, though rare, have shown high anti-CCP levels, prompting further medical evaluation when present.
You should choose Diagnopein for your ANTI CCP (CYCLIC CITRULLNATED PEPTIDE ) test because we are committed to providing high-quality diagnostic care in a clean and hygienic environment. Our center is equipped with advanced technology to ensure accurate and reliable test results, which are crucial for assessing this test. Diagnopein’s experienced staff is dedicated to handling tests with precision and care, offering you both expertise and comfort. We also offer affordable pricing, making essential health diagnostics accessible without compromising quality. For timely, professional, and affordable cardiac testing, Diagnopein is your trusted partner for your healthcare.
The normal range is typically between 0 and 20 U/mL. Levels above this range may suggest RA or other autoimmune conditions.
A positive Anti-CCP test often indicates rheumatoid arthritis and may suggest a more aggressive disease course, requiring close monitoring and potential treatment.
Low cyclic citrullinated peptide levels, or a negative result, are generally within the normal range and suggest a low likelihood of rheumatoid arthritis.
Although rare, high Anti-CCP levels have been detected in some cancer cases. Additional tests are typically required to determine the underlying cause.
High levels indicate RA risk, and your healthcare provider may suggest medications, lifestyle changes, and regular monitoring to manage the condition.
Individuals with symptoms of joint pain, swelling, or stiffness, or those with a family history of RA, should consider an Anti-CCP test to assess their risk.
Both tests aid in diagnosing RA, but Anti-CCP is more specific and can detect RA earlier than the RF test. A positive Anti-CCP result is more predictive of RA.
It’s possible, though uncommon. High Anti-CCP levels are highly specific to RA but can appear in other conditions, so follow-up with a healthcare provider is essential.
