Calcitonin is a hormone produced primarily by the parafollicular cells, or C cells, of the thyroid gland.
This hormone plays a crucial role in calcium homeostasis by lowering blood calcium levels when they become elevated. It does this by inhibiting osteoclast activity in the bones (cells that break down bone tissue), reducing renal tubular reabsorption of calcium, and promoting calcium excretion through the kidneys. The Serum Calcitonin test measures the level of this hormone in the blood and is primarily used in the diagnosis and management of certain medical conditions, including medullary thyroid carcinoma and other calcium metabolism disorders.
The Serum Calcitonin test involves a straightforward blood draw. A healthcare professional will collect a sample from a vein, usually in the arm. The blood sample is then sent to a laboratory for analysis, where calcitonin levels are measured, typically expressed in picograms per milliliter (pg/mL).
In some cases, the test may be performed after stimulation with calcium or pentagastrin to evaluate how well the body responds in terms of calcitonin secretion. This dynamic testing can help distinguish between normal physiology and pathological conditions.
Normal serum calcitonin levels are generally low, often below 10 pg/mL, although reference ranges may vary by laboratory. Elevated levels of calcitonin can suggest several conditions:
1] Medullary Thyroid Carcinoma: Significantly elevated calcitonin levels (often above 100 pg/mL) are strongly indicative of MTC and may guide further diagnostic imaging or biopsies.
2] C Cell Hyperplasia: Increased calcitonin levels may also be seen in cases of C cell hyperplasia, a non-cancerous proliferation of parafollicular cells.
3] Other Conditions: Elevated calcitonin can occur in other scenarios, such as certain neuroendocrine tumors, chronic renal failure, and conditions associated with hypercalcemia, although these instances are less common.
At Diagnopein, we offer comprehensive, accurate, and timely diagnostic services, including the Serum Calcitonin Test. With our best pathology lab for blood test,cutting-edge technology, and skilled technicians, you can be assured of reliable results every time. Get your results quickly, especially when time is crucial in detecting severe infections.
Competitive pricing without compromising on quality. Our team of experienced professionals ensures the test is conducted smoothly with minimal discomfort. We provide not just the Serum Calcitonin Test results but insights into your health condition, helping you and your doctor make informed decisions about treatment. For more information call us at +91 9204 108108.
Abnormal calcitonin levels may necessitate further investigations, such as imaging studies or biopsies, to identify underlying conditions or malignancies. Your healthcare provider will recommend appropriate next steps based on your results.
Generally, no special preparations are required. However, it’s advisable to inform your healthcare provider of any medications you are taking, as some can affect calcitonin levels.
This test is mainly performed to diagnose medullary thyroid carcinoma (MTC), especially in patients with a family history of the disease. It may also be used to evaluate C cell hyperplasia and assess calcium-related disorders.
Yes, calcitonin levels can be influenced by factors such as acute stress, renal failure, or certain medications. Therefore, elevated results should be interpreted carefully in the context of the patient's overall health.
