PNH is an acquired disorder caused by a mutation in the PIGA gene, which leads to the deficiency of certain glycosylphosphatidylinositol (GPI)-anchored proteins on the surface of blood cells.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and serious blood disorder characterized by the destruction of red blood cells (hemolysis) and the release of hemoglobin into the urine. This condition can lead to various complications, including thrombosis and bone marrow failure. The diagnosis of PNH relies on advanced laboratory techniques, particularly flow cytometry, which allows for the detailed analysis of blood cells and the identification of specific markers associated with the disorder.
1] Rapid and Accurate Diagnosis - Flow cytometry offers a rapid and sensitive method for diagnosing PNH. Unlike traditional methods, which may take longer and require multiple tests, flow cytometry can provide results within hours. This is particularly important in clinical settings where timely diagnosis can impact treatment decisions.
2] Differentiating PNH from Other Conditions - PNH can share symptoms with other hematological disorders, such as aplastic anemia and myelodysplastic syndromes. Flow cytometry helps differentiate PNH from these conditions by identifying the specific pattern of GPI-anchored protein deficiency. This diagnostic precision is essential for determining the appropriate management strategy.
3] Monitoring Disease Progression - In addition to diagnosis, flow cytometry can be used to monitor disease progression and treatment response in patients with established PNH. By regularly assessing the percentage of abnormal cells, healthcare providers can evaluate the effectiveness of therapies and make necessary adjustments.
At Diagnopein, we offer comprehensive, accurate, and timely diagnostic services, including the Paroxysmal Nocturnal Hemoglobinuria(PNH) Test. With our NABL-accredited labs, cutting-edge technology, and skilled technicians, you can be assured of reliable results every time. Get your results quickly, especially when time is crucial in detecting severe infections.
Competitive pricing without compromising on quality. Our team of experienced professionals ensures the test is conducted smoothly with minimal discomfort. We provide not just the Paroxysmal Nocturnal Hemoglobinuria(PNH), Flow Cytometry test results but insights into your health condition, helping you and your doctor make informed decisions about treatment. For more information call us at +91 9204 108108.
The test is low-risk, primarily involving a blood draw. Potential risks include minor discomfort, bruising, or infection at the puncture site.
A blood sample is drawn from the patient, and flow cytometry is used to analyze the red blood cells for the absence of GPI-anchored proteins (e.g., CD55 and CD59), which indicates PNH.
The test is performed to diagnose PNH, especially in patients exhibiting symptoms such as dark-colored urine, fatigue, and unexplained anemia. It helps differentiate PNH from other hematological disorders.
While the PNH test is critical for diagnosis, it may be used alongside other tests, such as complete blood counts and hemoglobin electrophoresis, to provide a comprehensive evaluation.
