Pregnancy Associated Plasma Protein-A (PAPP-A) is a protein produced by the placenta during pregnancy.
It plays a critical role in fetal development and is used as a biomarker in prenatal screening. The PAPP-A test measures the levels of this protein in a pregnant woman’s blood, providing valuable information about the health of both the mother and the fetus. This test is particularly important in the context of screening for chromosomal abnormalities and assessing the risk of complications during pregnancy.
1] Sample Collection - The test involves a simple blood draw, usually taken from a vein in the arm. The sample is then sent to a laboratory for analysis.
2] Laboratory Analysis
A] Measurement of PAPP-A Levels: The laboratory uses immunoassay techniques to measure the concentration of PAPP-A in the blood sample. This may involve enzyme-linked immunosorbent assays (ELISA) or similar methods.
B] Interpretation of Results: PAPP-A levels are interpreted in conjunction with other factors, including maternal age, gestational age, and results from other screening tests. This comprehensive evaluation helps calculate the risk of chromosomal abnormalities.
1] Normal Range - Normal PAPP-A levels can vary depending on gestational age, but generally, higher levels are expected in the first trimester. Typical values can range from 0.2 to 2.5 multiples of the median (MoM), but specific reference ranges may differ between laboratories.
2] Abnormal Results -
A] Low PAPP-A Levels: Low levels of PAPP-A (below the expected range) can indicate an increased risk of:
a] Down syndrome and other chromosomal abnormalities
b] Fetal growth restriction
c] Pregnancy complications, such as preeclampsia or placental abruption
B] High PAPP-A Levels: Elevated PAPP-A levels are generally less concerning but may require further investigation to rule out potential issues.
3] Follow-Up Testing - If PAPP-A levels are found to be abnormal, additional tests may be recommended, such as:
a] Non-invasive prenatal testing (NIPT) for chromosomal abnormalities
b] Targeted ultrasounds to assess fetal growth and anatomy
c]Amniocentesis or chorionic villus sampling (CVS) for definitive genetic testing
At Diagnopein, we offer comprehensive, accurate, and timely diagnostic services, including the PAPP A Test. With our NABL-accredited labs, cutting-edge technology, and skilled technicians, you can be assured of reliable results every time. Get your results quickly, especially when time is crucial in detecting severe infections.
Competitive pricing without compromising on quality. Our team of experienced professionals ensures the test is conducted smoothly with minimal discomfort. We provide not just the PAPP A (Pregnancy Associated Plasma Protein - A) test results but insights into your health condition, helping you and your doctor make informed decisions about treatment. For more information call us at +91 9204 108108.
1. PAPP-A (Pregnancy Associated Plasma Protein)
A blood sample is collected from a vein in the arm. The sample is sent to a laboratory for analysis to measure the concentration of PAPP-A in the blood.
Yes, maternal age, weight, ethnicity, and whether the pregnancy is a singleton or multiple can all influence PAPP-A levels. These factors are considered when interpreting test results.
The test helps identify women who may be at increased risk for conditions such as Down syndrome (trisomy 21) and other chromosomal abnormalities. It also provides insights into fetal growth and placental health.
The PAPP-A test is a non-invasive blood test, posing minimal risk to both the mother and the fetus. The primary risk is related to the blood collection process, which may cause minor discomfort or bruising.
